Diversity Libraries

Pre-selected diversity libraries for HTS and chemical biology

ChemBridge draws from its extensive stock to create pre-selected, pre-plated diversity libraries that provide our clients access to small molecule libraries offering diverse chemotypes and pharmacophores at attractive prices. These diversity libraries are available at lower minimum masses, allowing users to purchase smaller amounts compared to custom, cherry-picked selections, and include the following libraries:

These diverse screening compound libraries are ideal starting points for clients looking for a wide range of diversity to screen against targets from many classes or where little biological information is available to support targeted or focused screening.

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DIVERSet™ Libraries

We offer two, complementary DIVERSet™ libraries: The DIVERSet™-EXP library and the DIVERSet™-CL library. Each library offers a diverse set of 50,000 compounds with extensive pharmacophore coverage for primary screening. Stringent druglike and desirable chemical group filters coupled with a 3D conformer analysis are used in selecting a premium set of 50,000 druglike compounds with maximum pharmacophore coverage and chemical diversity:

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for more details on the DIVERSet™ libraries

The DIVERSet™ libraries are ideal tools for initial screening programs that require high diversity and quality druglike and leadlike compounds, and the two, complementary sets can be combined to create a 100,000 compound library that maintains overall diversity. Subsets starting at 10,000 compounds can be purchased from either DIVERSet™ library, and both are available in 96-well and 384-well format.

PremiumSet

Our PremiumSet draws from both our EXPRESS-Pick™ Collection stock and our CORE Library stock. The PremiumSet provides a library of 50,000 compounds that have been selected to provide 2D diversity and also offer the most attractive features found in druglike and leadlike compounds. Based on almost two decades of experience providing commercial screening libraries and the production of hundreds of exclusive libraries for major clients, ChemBridge has developed our proprietary SCORE program that not only identifies compounds with undesirable chemical features but also recognizes features considered to be highly attractive by researchers working in drug discovery and chemical biology. The PremiumSet does not cover all diversity available from ChemBridge’s small molecule screening libraries, as it is limited to a total of 50,000 compounds, but it features some of the most diverse and attractive compounds available across our two major stocks (EXPRESS-Pick™ Collection and CORE Library). Subsets of <50,000 compounds are available, and the PremiumSet can be provided in 96-well or 384-well format.

CombiSet

The 30,000-compound CombiSet also offers a selection of compounds from our CORE Library stock at a lower cost point than a custom, cherry-picked selection. Multiple scaffolds are represented, with a sampling of final compounds around each of the scaffolds. Subsets of 10,000 and 20,000 compounds are available, and the CombiSet can be provided in 96-well or 384-well format.

MicroFormat Library

The MicroFormat Library provides up to 180,000 compounds from the more than 500,000 compound EXPRESS-Pick™ Collection stock in pre-plated format, offering access to a large number of compounds at an attractive price point. MicroFormat compounds can be combined with DIVERSet™, PremiumSet or CombiSet compounds to expand to larger library sizes using pre-plated formats. Available in 96-well or 384-well format.


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