Diversity Libraries

Pre-selected diversity libraries for HTS and chemical biology

ChemBridge draws from its stock to create pre-selected and pre-plated sets that provide our clients access to libraries offering diverse chemotypes and pharmacophores at attractive prices. These libraries are available at lower minimum masses, allowing users to purchase smaller masses compared to custom, cherry-picked selections, and include the following libraries:

These libraries are ideal starting points for clients looking for a wide range of diversity to screen against targets from many classes or where little biological information is available to support targeted or focused screening.

DIVERSet

ChemBridge’s DIVERSet™ library provides a highly diverse library of 50,000 compounds for primary screening. Stringent druglike and desirable chemical group filters, coupled with a 3D pharmacophore diversity analysis, are used in selecting a premium set of druglike compounds with maximum pharmacophore diversity. DIVERSet™ is selected from ChemBridge’s EXPRESS-Pick™ Collection of 490,000+ handcrafted compounds.

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The DIVERSet™ library is an ideal tool for initial screening programs that require high diversity and quality druglike and leadlike compounds. DIVERSet™ is a well recognized and proven primary screening tool for a wide range of both validated and new biological targets; please click here to learn more about publications citing the DIVERSet Library.

PremiumSet

Our PremiumSet draws from both our EXPRESS-Pick Collection and our Combinatorial Libraries. The PremiumSet provides a library of 50,000 compounds that have been selected to provide 2D diversity but also offer the most attractive features found in druglike and leadlike compounds. Based on more than a decade of experience providing commercial screening libraries and the production of hundreds of exclusive libraries for major clients, ChemBridge has developed our proprietary SCORE program that not only identifies compounds with undesirable chemical features but also recognizes features considered to be highly attractive by researchers working in drug discovery and chemical biology. The PremiumSet does not cover all diversity available from ChemBridge’s screening compounds libraries, as it is limited to a total of 50,000 compounds, but it features some of the most diverse and attractive compounds available across our two major libraries. Available in 96-well or 384-well format.

There is no overlap between compounds of the DIVERSet Library and the EXPRESS-Pick Collection compounds that are included in the PremiumSet, which allows clients to combine these two sets.

CombiSet

For clients that would like to access some the diversity available from our Combinatorial Libraries at a lower cost point than a custom, cherry-picked selection, ChemBridge has created the CombiSet. The 30,000 compounds CombiSet is composed of compounds from our NOVACore and PHARMACophore Libraries, two of the sub-libraries that make up our Combinatorial Libraries. Multiple scaffolds are represented, with a sampling of final compounds around each of the scaffolds. Available in 96-well or 384-well format.

There is no overlap between compounds of the CombiSet and the Combinatorial Libraries compounds that are included in the PremiumSet, which allows clients to combine these two sets. Clients can also combine the DIVERSet and CombiSet, as each comes from a separate part of our stock and there is no overlap of compounds.

MicroFormat Library

The MicroFormat Library provides up to 180,000 compounds from the 450,000+ compound EXPRESS-Pick Collection in pre-plated format, offering access to a large number of compounds at an attractive price point. MicroFormat compounds can be combined with DIVERSet, PremiumSet or CombiSet compounds to expand to larger library sizes using pre-plated formats. Available in 96-well or 384-well format.


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