Screening Libraries: Key Facts


Small molecule screening libraries for drug discovery and chemical biology

High Quality, Small Molecule Screening Libraries

ChemBridge has been a provider of high quality screening compounds and libraries for two decades and continues to produce novel, druglike and leadlike screening compounds based on the evolving requirements of drug discovery and chemical biology researchers in industry and academia.

We currently offer more than 1 million druglike and leadlike screening compounds that are readily available from stock. Clients can custom select compounds from our two, non-overlapping stocks (EXPRESS-Pick Collection and CORE Library) or can choose from our selection of diversity or targeted/focused sets. To search our compounds online or to place an order online, clients can use our Hit2Lead.com Online Chemical Store, which offers ID and structure searches with up to date availability and discount pricing along with access to our San Diego-based Rush stock.

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to view a PDF summary of our two stocks.



EXPRESS-Pick Collection Stock

This collection of small molecule screening compounds contains over 500,000 handcrafted chemical compounds. Our EXPRESS-Pick Collection stock compounds (7-digit IDs) are selected using novelty, diversity, druglike properties, and chemical structure analyses based on almost two decades of library design and medicinal chemistry experience. The EXPRESS-Pick Collection stock covers a broad area of chemical space, offering diverse classes of compounds with analogs to support initial SAR work. Clients can custom-select from the EXPRESS-Pick™ Collection stock, and ChemBridge draws from this collection to create diversity libraries such as the DIVERSet™-EXP, PremiumSet, and MicroFormat, to create our Fragment Library, and to create targeted/focused offerings such as the KINASet, CNS-Set, and ION Channel Set. Delivery in mg or umol amounts is available as DMSO solutions or dried samples.

CORE Library Stock

Our in-house designed CORE Library of small molecule screening compounds (8-digit IDs) offer more than 490,000 compounds and are produced from over 560 novel scaffolds synthesized by ChemBridge with final compounds drawing on our Building Block Collection. These compounds are designed to cover unique chemical space not available from our EXPRESS-Pick™ Collection stock or other commercial libraries. The newest CORE Library scaffolds are SP3-enriched to reflect the increasing interest in 3D structures. Clients can custom-select from the CORE Library stock, and ChemBridge draws from the CORE Library stock to create diversity libraries such as the DIVERSet™-CL, PremiumSet, and CombiSet and targeted/focused offerings such as the GPCR, KINACore, NHRCore and IONCore libraries. Delivery in mg or umol amounts is available as DMSO solutions or dried samples.

Successful Track Record

Experience

Two decades of excellence as a chemistry service provider/partner, including major, multi-year alliances with top pharmaceutical companies.

Deliverability

Over 20 million samples provided to more than 500 satisfied clients worldwide, including all major pharmaceutical and biotechnology companies as well as major academic and non-profit research organizations. We pride ourselves on consistently meeting custom chemistry project deadlines.

Successful HTS Campaigns

More than 1,000 scientific articles that cite ChemBridge libraries or compounds have been published in premier journals, such as Science, Nature Cell Biology, JACS, PNAS, JBC, Cancer Research, and others.

For more information, contact sales@chembridge.com

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