Screening Libraries: Key Facts

Small molecule screening libraries for drug discovery and chemical biology

Small Molecule Libraries

ChemBridge maintains a stock of more than 900,000 druglike and leadlike screening compounds ready for shipment to our clients. Over 750,000 of these compounds are at higher stock levels and supported by re-supply amounts, with the remaining compounds available to fulfill re-supply orders and smaller, focused compound acquisitions. All compounds are available from our Hit2Lead.com Online Chemical Store, which offers ID and structure searches and up to date availability and discount pricing. Structures for our higher stock compounds are available for download from the Databases page (SDfile or ISIS .db file formats).

Our stock of higher availability compounds is divided into two main, non-overlapping groups:

  • The EXPRESS-Pick Collection, and
  • Our Combinatorial Libraries

EXPRESS-Pick Collection

This collection of small molecule screening compounds contains over 500,000 handcrafted chemical compounds (7-digit IDs). Our stock compounds are selected using novelty, diversity, druglike property analysis, and medicinal chemistry expertise. Clients can custom-select from the EXPRESS-Pick Collection, and ChemBridge draws from this collection to create diversity libraries such as the DIVERSet, PremiumSet, and MicroFormat library and targeted and focused offerings such as the KINASet, CNS-Set, and ION Channel Set.

Combinatorial Libraries

Our in-house designed Combinatorial Libraries offer more than 300,000 compounds (8-digit IDs) and are produced from over 300 novel scaffolds synthesized by ChemBridge with final compounds drawing from our Building Block Collection. These compounds are designed to cover unique chemical space not available from our EXPRESS-Pick Collection or other commercial libraries. Our Combinatorial Libraries include the:

  • NOVACore Library
  • PHARMACophore Library
  • GPCR Library
  • KINACore Library
  • IONCore Library
  • NHRCore Library

New small molecules are synthesized each year and added on a monthly basis. Clients can custom-select from these libraries, and our PremiumSet and CombiSet diversity libraries offer economical access to compounds pre-selected from the Combinatorial Libraires.

Successful Track Record

Experience

Almost two decades of excellence as a chemistry service provider/partner, including major, multi-year alliances with top pharmaceutical companies. Click here to view Press Releases.

Deliverability

Over 20 million samples provided to more than 500 satisfied clients worldwide, including all major pharmaceutical and biotechnology companies as well as major academic and non-profit research organizations. We pride ourselves on consistently meeting custom chemistry project deadlines.

Advanced Leads

Obtained by our clients in a variety of HTS programs; numerous examples of success and discoveries published in premier journals, such as Science, Nature Cell Biology, JACS, PNAS, JBC, Cancer Res., etc.

Innovations

Continuous establishment of new industry standards:

1995:
Pioneering 3D pharmacophore diversity library (DIVERSet™)
1996:
100% QC guarantee and 100% bar-code-based sample processing
1998:
Therapeutic area focused screening set (CNS-Set™)
2000:
DMSO pre-plated sets with druglike properties (MICROFormats™)
2000:
The design and synthesis of novel templates leading to the PHARMACophore library
2000:
Launch of our Hit2Lead.com online chemical store
2005:
Leadlike diverse library with improved properties (NOVACore Library)
2007:
Launch of re-designed Hit2Lead.com site with enhanced features based on client input
2002/2008:
Targeted and focused libraries based on the 3D pharmacophore design
2010:
Expansion of North America-based Rush stock with new package size

For more information, contact sales@chembridge.com

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