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Leveraging ChemBridge Small Molecule Screening Libraries in Cancer Research

San Diego, California, June 10, 2016

More than 1,500 articles cite the use of ChemBridge™ small molecule screening libraries and compounds in a wide variety of research areas using high-throughput screening or focused screening following computer-aided screening. The list below highlights a small sampling of articles, from 2014 to present, that focus on work in cancer research and provides a sample of the different techniques employed and targets explored in hit finding and probe discovery using ChemBridge libraries and compounds. Click here.

Identification of a Selective G1- Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks Bilsland AE, et al.; Neoplasia. 2015 Sep;17(9):704-15. PMID 26476078. The authors identified CB-20903630, as a senescence associated beta-galactosidase inhibitor using virtual screening as the primary screen

Estrogen receptor alpha inhibitor activates the unfolded protein response, blocks protein synthesis, and induces tumor regression Andruska ND, et al.; Proc Natl Acad Sci U S A. PMID 25825714. The authors identified BHPI (ChemBridge ID 6373538) as an estrogen receptor alpha biomodulator using a high-throughput screen as the primary screen.

A novel pyruvate kinase M2 activator compound that suppresses lung cancer cell viability under hypoxia Kim DJ, et al.; Mol Cells. 2015 Apr;38(4):373-9. PMID 25813626. The authors identified PA-12 (ChemBridge ID 7871820) as pyruvate kinase M2 activator using a virtual screen as the primary screen.

Anticancer/Antiviral Agent Akt Inhibitor-IV Massively Accumulates in Mitochondria and Potently Disrupts Cellular Bioenergetics Meinig JM and Peterson BR.; ACS Chem Biol. 2015 Feb 20;10(2):570-6. PMID 25415586. The authors had previously identified AKTIV (Akt Inhibitor-IV; ChemBridge ID 5233705) as an PI3-kinase/Akt (protein kinase B) inhibitor and focused on elucidation of the mechanism of action.

Targeted inhibition of cell-surface serine protease Hepsin blocks prostate cancer bone metastasis Tang X, et al.; Oncotarget. 2014 Mar 15;5(5):1352-62 PMID 24657880. The authors had previously identified HepIN-13 (ChemBridge ID 5717483) as serine protease Hepsin inhibitor and focused on the development, analysis and animal trial of the inhibitor.

Structure-based discovery of a small non-peptidic Neuropilins antagonist exerting in vitro and in vivo anti-tumor activity on breast cancer model Borriello L et al. ; Cancer Lett. 2014 Jul 28;349(2):120-7. PMID 24752068. The authors identified Compound 1 (ChemBridge ID 7967674) as a neuropilins (non-tyrosine kinase receptor) antagonist using a virtual screen as the primary screen.

Activation of the Proapoptotic Bcl-2 Protein Bax by a Small Molecule Induces Tumor Cell Apoptosis Zhao G et al.; Mol Cell Biol. 2014 Apr;34(7):1198-207. PMID 24421393. The authors identified Compound 106 (ChemBridge ID 78872106) as a proapoptotic Bcl-2 protein Bax activator using a virtual screen as the primary screen.

Discovery of SIRT3 Inhibitors Using SAMDI Mass Spectrometry Patel K et al.; J Biomol Screen. 2015 May 29. PMID 26024947. The authors identified SDX-437 (ChemBridge ID 7706915) as a sirtuin deacytelase 3 (SIRT3) inhibitor using a high-throughput screen.

For a complete list of publications, contact sales@chembridge.com.

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